The science
Every ingredient, the dose, and the evidence.
This is the whole formula with the reasoning and the published research behind each part, including the studies that do not say what a marketing page would want them to say.
The amounts below are targets. They are what Replenish is formulated to deliver and they are not final until the first production run is confirmed. When it is, the Supplement Facts panel publishes on the ingredients page and this page is updated to match.
How to read this page
Three things are worth saying before the list.
A supplement supports; it does not treat
Every claim on this page is a structure/function statement and carries a dagger linking to the FDA disclaimer. None of it is a claim to diagnose, treat, cure or prevent anything, and none of it is advice about your own situation.
The dose is the claim
An ingredient at a token amount is decoration. Each entry gives the amount, what share of the Daily Value that is, and how far it sits below the upper limit, so you can judge it.
Evidence is cited as it is, not as we would like it
Where a study used a much larger dose than ours, it says so. Where a trial was funded by an ingredient manufacturer, it says so. A citation that needs those caveats hidden is not support.
The formula
Sodium and potassium, as citrates
120 mg sodium, 120 mg potassium. The main cations outside and inside your cells. They help maintain normal fluid balance†
Why this dose. 120 mg of sodium is about 5% of the 2,300 mg daily limit; 120 mg of potassium is about 3% of the Daily Value. These are small amounts meant to accompany a glass of water, not to replace losses from illness. Replenish is not an oral rehydration solution: it has no glucose and far less sodium than one.
Evidence. Weaver CM. Potassium and health. Adv Nutr 2013. PMID 23674806. Aburto NJ et al. BMJ 2013. PMID 23558164 — studied intakes far above this dose.
Ask your clinician if you have chronic kidney disease, or take an ACE inhibitor, an ARB or a potassium-sparing diuretic, or follow a sodium-restricted diet.
Magnesium, as magnesium citrate
50 mg. A cofactor in more than 300 enzyme systems, including normal muscle and nerve function and normal energy metabolism†
Why this dose. 12% of the Daily Value, about one seventh of the supplemental upper limit. Chosen to add to what you already eat without the osmotic laxative effect larger doses can have.
Why citrate. Better absorbed than oxide in small trials: Lindberg JS et al. J Am Coll Nutr 1990. PMID 2407766. Walker AF et al. Magnes Res 2003. PMID 14596323. Review: de Baaij JHF et al. Physiol Rev 2015. PMID 25540137.
Ask your clinician if you have reduced kidney function. Separate it from tetracyclines, quinolones, bisphosphonates and levothyroxine.
Calcium, as calcium citrate
110 mg. Structural in bone and teeth; involved in normal muscle contraction and nerve signalling†
Why this dose. 8% of the Daily Value. A contribution to the day, not a calcium supplement — if you have been told to take one, this does not replace it.
Why citrate. Absorbs somewhat better than carbonate and does not depend on stomach acid, which matters when you are eating little. Sakhaee K et al. Am J Ther 1999. PMID 11329115.
Ask your clinician if you have a history of calcium kidney stones. Separate it from levothyroxine, tetracyclines, quinolones and bisphosphonates.
Zinc, as zinc citrate
5 mg. Supports normal immune function and normal protein synthesis†
Why this dose. 45% of the Daily Value, about one eighth of the 40 mg upper limit. Copper depletion is reported at long-term intakes far above this.
Why citrate. Absorbed as well as gluconate and better than oxide. Wegmüller R et al. J Nutr 2014. PMID 24259556 — fifteen healthy adults at 10 mg, funded by a citrate manufacturer, which is worth knowing. Review: Wessels I et al. Nutrients 2017. PMID 29186856.
Ask your clinician if you take quinolone or tetracycline antibiotics, or penicillamine.
Prebiotic fiber: partially hydrolysed guar gum
3,000 mg. A soluble prebiotic fiber that supports regularity†
Why this one. PHGG dissolves clear in cold water instead of thickening, which is why it is the fiber in a drink you are meant to finish. It is named and measured on the panel rather than hidden inside a blend.
Why this dose. 3 g is a meaningful addition to a day that is short on fiber without being the whole day's intake. Fiber needs fluid to work, so drink the full glass.
Worth knowing. Adding fiber quickly can cause bloating or wind. Build up over a week rather than starting at a full scoop if you are sensitive.
Vitamins C, D3, B1, B6, folate and B12
These are the vitamins that come from finishing a plate, and the ones a smaller plate supplies less of. They support normal immune function, normal energy metabolism and normal bone health†
Doses. Vitamin C 125 mg. Vitamin D3 10 mcg (400 IU). Thiamin 1.2 mg. Vitamin B6 2 mg. Folate 200 mcg DFE, as L-5-methyltetrahydrofolate rather than folic acid. Vitamin B12 200 mcg, as methylcobalamin.
Why those forms. L-5-MTHF is the circulating form of folate and does not depend on the MTHFR enzyme step. Methylcobalamin is a form the body uses directly.
Ask your clinician if you are being monitored for B12 or vitamin D, or take levodopa, methotrexate or an anticonvulsant.
Flavour, sweetness and bulk
Ginger root extract, 5 mg. For flavour. It rounds out the lemon-lime. That is the whole reason it is there.
Monk fruit extract and Reb M. Sweetness without sugar.
Erythritol, about 1,800 mg. Bulk and a little sweetness, so a scoop is a scoop.
Citric acid, natural lemon-lime flavour, silicon dioxide. Acidity, taste, and keeping the powder free-flowing.
None of these four are doing anything for your body. They are listed because they are in the tub.
What is deliberately left out
No caffeine. No maltodextrin. No proprietary blends. No added sugar. No protein — a drink is the wrong vehicle for it, and that is what Nourish is for.
Nothing here is included at a dose chosen to look impressive on a label. Where an amount is modest, this page says so.
Amounts are targets pending the first production run. Daily Values are based on a 2,000 calorie diet.